LYN

109.99 $

Super concentrated formula

10


RAD150

20


MK677

**These statements have not been evaluated by the Food and Drug administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.
*All amounts per 1Ml serving

LYN formulation

RAD 150, also known as TLB 150, is the esterified version of the popular SARM, RAD 140. RAD 140 has been studied most thoroughly on male gonadectomized rats suffering from neurodegenerative decline due to decreased androgen levels. Overall, the fascinating study conducted by Jayaramen et. Al came to the conclusion that in male rats, supplementation with RAD 140 had neuroprotective effects on the brain via MAPK signaling. Additionally, the study found that treatment with RAD 140 was actually just as effective in protecting against cell death as testosterone treatment Study.. In addition to providing neuroprotection, testing of RAD 140 in juvenile monkeys over a 28 day period was shown to have led to an average of 10% increase in body weight. Through the use of DEXA scans it was found that the weight gain was primarily lean muscle mass.

Esterification occurs when a substitution reaction takes place. The specific substitution reaction that occurs when a compound becomes an ester, is derived from a carboxylic acid. The hydroxyl group (-OH) of the carboxylic acid is replaced with an alkyl (-O-) group. Esterification occurs when the carboxylic acid is exposed to heat and a strong acid, normally sulphuric acid. In some cases, various other strong acids such as hydrochloric acid will be used in order to catalyze the substitution reaction Study..

RAD 150 is the esterified version of RAD 140. The main structural difference between the two compounds is the group of benzoate esters that were added during the substitution reaction of esterification. Adding the group of benzoate esters increases the alkalinity of the compound thus making it more stable than RAD 140 itself Study.. In order to synthesize RAD 150 from Testolone, it has to undergo the process of esterification. During the substitution reaction, a group of benzoate esters is added to Testolone in order to turn the compound into its esterified version, accounting for the main structural difference between the two compounds. By adding the benzoate ester group, the compound now has increased alkalinity, thus indicating that the esterified compound is more stable than Testolone Study. Additionally, in a similar fashion to other esterified SARMs, the bioavailability and the half-life of RAD 150 are increased. With increased bioavailability, the compound is absorbed much faster, and with increased half-life the compound is active for far longer than RAD 140, the nonesterified compound. This indicates that by esterifying RAD 140 there are additional potential benefits that are added. Furthermore, when comparing Testolone to RAD 150, RAD 150 is similar to other esterified SARMs with an increase in half-life and bioavailability. By increasing the half-life of RAD 150, the compound is considered active for a longer period of time than when supplementation with Testolone. Additionally, when bioavailability is increased, the compound is absorbed at a faster rate. It can be concluded that when Testolone undergoes esterification, there are several additional benefits that can be derived from the resulting compound, RAD 150.

MK-677 is a long-acting, ghrelin receptor agonist and Human Growth Hormone stimulator, spiroindoline sulfonamide. It is also known as Ibutamoren, MK-677, L-163, 191, and formerly known as Oratrope. In a study performed by Jacks et. Al published in Endocrinology in 199g, 8 beagles were given MK-677 at doses of 0.25mg/kg, and it was found that Growth Hormone (GH) levels increased 5.3 times over baseline. At the 0.5mg/kg dose, GH levels increased 9 times over baseline GH rates, and at the 1mg/kg dose range, the GH levels increased by nearly 16 times that of baseline (15.8). It’s important to note that these doses were oral vs. intravenous or intramuscular injection. Insulin-like growth factor remained elevated by 30% after 8 hours, indicating MK-677 is a long-acting compound in beagles. GH was also elevated up to 6 hours. Study authors mentioned that cortisol was also elevated, however, it was modest compared to those in GH. But MK-677 is not just a GH secretagogue, it is also an orally active gherkin receptor agonist, meaning it will work on the ghrelin receptors. As explained by Zhang et al, “The ‘hunger hormone’ ghrelin activates the ghrelin receptor GHSR to stimulate food intake and growth hormone secretion and regulate reward signaling.” In addition to its role in hunger signaling, it also modulates stress, glucose, body weight, cognition, gut motility, the desire for food, adiposity, and even pain. An extensive study of MK-677’s chemical makeup in relation to ghrelin itself by Zhang’s research group discovered that MK-677 (termed Ibutamoren by their study), “mimics the first four N-terminal residues of ghrelin including the octanoyl moiety to bind at the bottom region of the ligand-binding pocket.” Study. If interested in the many target organs of ghrelin, see the following image at the link: Study. An interesting impact of MK-0677 on the ghrelin agonist that stimulates the GHS-R1a receptor has been shown to increase neural activity and decrease the death of neurons and neuroinflammation. In a study published in the International Journal of Molecular Sciences, researchers Jeong et. al, gave MK-677 to mice who were genetically predisposed to overexpress amyloid beta-peptide or Aβ, a protein responsible for the plaques and tangles shown in Alzheimer’s diseased brains. These mice were given MK-0677 via injection, at dose levels of 0.1, 1, and 3mg/kg for ten days. The second two groups had increased food intake through the ten-day study period, especially at the 3mg/kg dosing level. However, at the end of the ten days, body weight did not significantly differ between all dosing groups. Examination of the brains of the treated groups showed decreased Aβ deposition and decreased neuronal, synaptic losses as well as glial changes in the deep cortical layers of the brain. Researchers concluded that MK-677 also reduced the neuroinflammation and neurodegeneration associated with Aβ. Study.

possible side effects

Not for human consumption, Please read the research papers related to this chemical before administration, Misuse of this product can result in dangerous side effects.