BIONIC
124.99 $
Super concentrated formula
50
S4
20
S23
50
S4
**These statements have not been evaluated by the Food and Drug
administration (FDA). This product is not intended to diagnose, treat,
cure, or prevent any disease.
*All amounts per 1Ml serving
BIONIC formulation
S-4 is a SARM more commonly known as Andarine, also has been called Androxolutamide and GTx-007. In a fascinating study conducted by Gao et. Al, S-4 was characterized as an androgen receptor agonist in orchidectomized rats, with the mechanism of action in the skeletal muscle, bones, and pituitary.
Male rats were treated with either 3 mg/kg or 10 mg/kg of S-4 12 weeks after castration over an 8 week period. The study showed that both the 3 mg/kg dose and 10 mg/kg dose were successful in restoring both muscle mass and strength in the soleus muscle as well as muscle mass in the levator ani muscle comparable to that of intact male rats Study. Treatment with S-4 also minimally impacted the weight of the prostate and the seminal vesicles by approximately 16-17%, however, the S-4 treatment had strong androgenic effects on the prostate and seminal vesicles.
S23 is an orally available selective androgen receptor modulator or SARM. Originally developed by GTX as a form of hormonal male contraception in rats,it exhibits a high affinity for the androgen receptor with a Ki of 1.7 nM. Researchers, Jones et. Al published a research study comparing the effectiveness of S-23 in both castrated and intact male rats.
In castrated male rats, the effective dose of S23 in the prostate was 0.43 mg/d and 0.079 mg/d in the levator ani muscle. In intact male rats, doses greater than 0.1 mg/d of S-23 suppressed levels of luteinizing hormone (LH) by more than 50%. Furthermore, this dose of S-23 corresponded with decreased size of the prostate and increased size of the levator ani muscle Study. In intact males treated with S-23 as well as estradiol benzoate (to maintain sexual behavior), after 10 weeks there was no sperm found in the testis in four out of the six subjects and no reported pregnancies in all six of the subjects. After the treatment, infertility was completely reversed and 100% of the mating trials resulted in pregnancy.
The effects of S23 on muscle mass and body fat are comparable to the effects of anabolic steroids. In a study conducted in male rats it was discovered that while being treated with S23, the overall body weight and fat mass of the rats decreased. As it was previously mentioned, rats being treated with S23 were also given estradiol benzoate (EB) to maintain sexual behavior. EB is considered an estrogen which is known to cause muscle loss, however, when combined with S23 the effects of the estrogen were canceled out and the muscle mass of the male rats increased Study. . Additionally, in another study using rats, the effectiveness of S23 was tested against muscle loss due to long-term usage of glucocorticoids. This study also looked into the effects of S23 on castration-induced atrophy. In both cases, there was muscle loss but by supplementing S23 and testosterone to the rats the dexamethasone-induced dephosphorylation of Akt is blocked. Overall this study indicated that using S23 may be a more effective way of treating glucocorticoid-induced muscle loss Study.
S-4 is a SARM more commonly known as Andarine, also has been called Androxolutamide and GTx-007. In a fascinating study conducted by Gao et. Al, S-4 was characterized as an androgen receptor agonist in orchidectomized rats, with the mechanism of action in the skeletal muscle, bones, and pituitary.
Male rats were treated with either 3 mg/kg or 10 mg/kg of S-4 12 weeks after castration over an 8 week period. The study showed that both the 3 mg/kg dose and 10 mg/kg dose were successful in restoring both muscle mass and strength in the soleus muscle as well as muscle mass in the levator ani muscle comparable to that of intact male rats Study. Treatment with S-4 also minimally impacted the weight of the prostate and the seminal vesicles by approximately 16-17%, however, the S-4 treatment had strong androgenic effects on the prostate and seminal vesicles.
possible side effects
Not for human consumption, Please read the research papers related to this chemical before administration, Misuse of this product can result in dangerous side effects.